The Handbook of Biomarkers by Kewal K. Jain
Author:Kewal K. Jain
Language: eng
Format: epub
Publisher: Springer New York, New York, NY
High levels of TS, the 5-FU target, are associated with tumor insensitivity to FU-based therapy.
Higher levels of topoisomerase-I (TOP1) correlate with greater sensitivity of colon tumors to camptothecin derivatives compared to normal colonic mucosa.
Glucuronidation, involved in xenobiotic detoxification, is also associated with innate resistance to TOP1 inhibitors in colon cell lines and tumors.
An increase of the ABCB1/P-gp transporter, a member of the family of ABC-transporters that detect and eject anticancer drugs from cells, is observed in intrinsically drug-resistant colon tumors.
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